DRO counts but no axis motion, no spindle, no coolant

YouTube video showing the issue:

Symptoms
PathPilot boots normally.
The machine successfully transitions to Machine Ready.
PathPilot correctly detects e-stop status.
However:
No X/Y/Z axis movement.
No spindle operation.
No coolant operation.
Coolant relay never actuates.
What I’ve checked:
Verified the E-stop circuit is functioning correctly.
Verified C1 energizes (red LED illuminates and remains on)
Reseated the DB25 cable and checked for defects
DRO increments normally when jogging/referencing (commands register software-side, no physical motion)
Ordered power cycle performed (mill + controller), no change
Fuse bank verified good (F1/F3/F6/F10)
BLDC spindle drive is powered on
No error messages are displayed in PathPilot

Since you have reseated the serial cable. You could also try and verify the terminal block wires are tight. Literally put a screwdriver on everyone and check they are tight.

Working in an industrial environment most of my life you would be surprised how often reseating cables and tightening terminal block lugs actually works when weird stuff happens. The slight vibration over time can cause things to loosen up. After that its a hardware troubleshooting kinda game.

The first thing you do in the video looks like you press the eStop button in. Is that right?

The e-stops on my machines are pulled outward for operation so its easy to smack down in case of emergency. Yours may be wired backwards if it needs to be in.

FWIW, Startup sequence for my 1100MX is power on, wait for PP to boot, pull up eStop button, press the physical reset button (makes a clunk), wait a couple seconds, press reset in PP (makes a click).